Journal
CEREBRAL CORTEX
Volume 20, Issue 11, Pages 2675-2683Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhq013
Keywords
anterior cingulate cortex; conflict; dorsolateral prefrontal cortex; functional magnetic resonance imaging; single-trial analysis
Categories
Funding
- Nissan Science Foundation
- Japan Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [21120007] Funding Source: KAKEN
Ask authors/readers for more resources
The prefrontal cortex (PFC) is thought to modulate the neural network state in favor of the processing of task-relevant sensory information prior to the presentation of sensory stimuli. However, this proactive control mechanism cannot always optimize the network state because of intrinsic fluctuation of neural activity upon arrival of sensory information. In the present study, we have investigated an additional control mechanism, in which the control process to regulate the behavior is adjusted to the trial-by-trial fluctuation in neural representations of sensory information. We asked normal human subjects to perform a variant of the Stroop task. Using functional magnetic resonance imaging, we isolated cognitive conflict at a sensory processing stage on a single-trial basis by calculating the difference in activation between task-relevant and task-irrelevant sensory areas. Activation in the dorsolateral PFC (DLPFC) covaried with the neural estimate of sensory conflict only on incongruent trials. Also, the coupling between the DLPFC and anterior cingulate cortex (ACC) was tighter on high-sensory conflict trials with fast response. The results suggest that although detection of sensory conflict is achieved by the DLPFC, online behavioral adjustment is achieved by interactive mechanisms between the DLPFC and ACC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available