Journal
TRENDS IN GENETICS
Volume 17, Issue 1, Pages 10-13Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0168-9525(00)02159-4
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Conservation of gene order in prokaryotes has become important in predicting protein function because, over the evolutionary timescale, genomes are shuffled so that local gene-order conservation reflects the functional constraints within the protein. Here, we compare closely related genomes to identify the rate with which gene order is disrupted and to infer the genes involved in the genome rearrangement.
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