Journal
CEREBRAL CORTEX
Volume 20, Issue 6, Pages 1398-1408Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhp203
Keywords
cortex; dendrite; development; Hebbian rule; spines; spontaneous activity
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Funding
- Japan Science and Technology Agency
- Ministry of Education, Culture, Sports, Science, and Technology (Japan) [17022025]
- Osaka University
- I Hear Innovation Foundation (Australia)
- Grants-in-Aid for Scientific Research [17022025] Funding Source: KAKEN
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Neocortical pyramidal cells are characterized by markedly different structure among cortical areas in the mature brain. In the ventral visual pathway of adult primates, pyramidal cells become increasingly more branched and more spinous with anterior progression through the primary (V1), second (V2), and fourth (V4) visual areas and cytoarchitectonic areas TEO and TE. It is not known how these regional specializations in neuron structure develop. Here, we report that the basal dendritic trees of layer III pyramidal cells in V1, V2, V4, TEO, and TE were characterized by unique growth profiles. Different numbers of spines were grown in the dendritic trees of cells among these cortical areas and then subsequently pruned. In V1, V2, and V4, more spines were pruned than grew resulting in a net decrease in the number of spines in the dendritic trees following the onset of visual experience. In TEO and TE, neurons grew more spines than they pruned from visual onset to adulthood. These data suggest that visual experience may influence neuronal maturation in different ways in different cortical areas.
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