Journal
CEREBRAL CORTEX
Volume 19, Issue -, Pages I55-I61Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhp042
Keywords
asymmetric division; neural progenitor; neuroepithelial cell; self-renewal; spindle orientation
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In mammalian brain development, neuroepithelial cells act as progenitors that produce self-renewing and differentiating cells. Recent technical advances in live imaging and gene manipulation now enable us to investigate how neural progenitors generate the 2 different types of cells with unprecedented accuracy and resolution, shedding new light on the roles of epithelial structure in cell fate decisions and also on the plasticity of neurogenesis.
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