Journal
CEREBRAL CORTEX
Volume 20, Issue 5, Pages 1071-1081Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhp168
Keywords
basal progenitors; cortical neurogenesis; cortical unit column; evolutionary biology of cerebral cortex; intermediate progenitors; Monodelphis domestica
Categories
Funding
- Medical Research Council [G0300200, G0700377]
- Biotechnology and Biological Sciences Research Council [BB/F003285/1]
- National Science Foundation [IOS-0743924]
- Direct For Biological Sciences [0743924] Funding Source: National Science Foundation
- Division Of Integrative Organismal Systems [0743924] Funding Source: National Science Foundation
- Biotechnology and Biological Sciences Research Council [BB/F003285/1] Funding Source: researchfish
- Medical Research Council [G0300200, G0700377] Funding Source: researchfish
- BBSRC [BB/F003285/1] Funding Source: UKRI
- MRC [G0700377, G0300200] Funding Source: UKRI
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The major lineages of mammals (Eutheria, Metatheria, and Monotremata) diverged more than 100 million years ago and have undergone independent changes in the neocortex. We found that adult South American gray short-tailed opossum (Monodelphis domestica) and tammar wallaby (Macropus eugenii) possess a significantly lower number of cerebral cortical neurons compared with the mouse (Mus musculus). To determine whether the difference is reflected in the development of the cortical germinal zones, the location of progenitor cell divisions was examined in opossum, tammar wallaby, and rat. The basic pattern of the cell divisions was conserved, but the emergence of a distinctive band of dividing cells in the subventricular zone (SVZ) occurred relatively later in the opossum (postnatal day [P14]) and the tammar wallaby (P40) than in rodents. The planes of cell divisions in the ventricular zone (VZ) were similar in all species, with comparable mRNA expression patterns of Brn2, Cux2, NeuroD6, Tbr2, and Pax6 in opossum (P12 and P20) and mouse (embryonic day 15 and P0). In conclusion, the marsupial neurodevelopmental program utilizes an organized SVZ, as indicated by the presence of intermediate (or basal) progenitor cell divisions and gene expression patterns, suggesting that the SVZ emerged prior to the Eutherian-Metatherian split.
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