Journal
TISSUE ANTIGENS
Volume 57, Issue 1, Pages 76-79Publisher
MUNKSGAARD INT PUBL LTD
DOI: 10.1034/j.1399-0039.2001.057001076.x
Keywords
allele frequency; HLA-B*07; HLA-B7 subtype; haplotype; Korean; PCR-SSCP
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Ne have investigated the frequencies of HLA-B*07 alleles and their haplotypic associations with HLA-A, -C and -DRB1 loci in 489 healthy unrelated Koreans, including 214 parents from 107 families. All of the 45 samples (9.2%) typed as B7 by serology were analyzed for B*07 alleles using polymerase chain reaction (PCR)-single strand conformation polymorphism (SSCP) method Two different B*07 alleles were detected: B*0702 (allele frequency 0.041) and B*0705 (0.005). Two characteristic haplotypes showing strong linkage disequilibrium in Koreans were A*2492-Cw*07-B*0702-DRB1*0101 (haplotype frequency 0.028) and A*2901-B*0705 DRB1*0803 (0.005). The characteristic haplotype A*2901-B*0705-DRB1*0803, found in 100% (5/5) of B*0705-positive individuals, has not been previously described in other ethnic groups. HLA-B7 alleles comprise distinctive extended haplotypes in the Korean population The probability of HLA-B7 allele mismatches among ABDR-matched unrelated donor-recipient pairs is expected to be low in Koreans.
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