Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 27, Issue 3, Pages 115-117Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0968-0004(02)02058-3
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A new subfamily of two-domain histone acetyltransferases (HATS) related to Elp3 has been identified. In addition to a HAT domain in the C terminus, these proteins have an N-terminal domain similar to the catalytic domain of S-adenosylmethionine radical enzymes. Two-domain organization is preserved in evolution, suggesting that both enzymatic activities are functionally or mechanistically coupled and directed towards highly conserved substrates. The functional implications of this similarity and a possible role for Elp3-related proteins as histone demethylases are discussed.
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