Journal
CEREBELLUM
Volume 12, Issue 5, Pages 707-712Publisher
SPRINGER
DOI: 10.1007/s12311-013-0485-8
Keywords
Ataxia; TMS; Cerebellum; EMG; Motor Cortex
Categories
Funding
- Canadian Institute of Health Research (CIHR) [201102MFE-246635-181538]
- Harvard-Thorndike Clinical Research Center at Beth Israel Deaconess Medical Center integrated in the Harvard Clinical and Translational Science Center from the National Center for Research Resources, National Institutes of Health [M01-RR-01066, UL1 RR025758]
- Bolsas de Viaje Esteban Martino of Fundacion Marques de Valdecilla [BEM 13/11]
- KL2 Medical Research Investigator Training (MeRIT) award from Harvard Catalyst [1KL2RR025757-04]
- Sidney Baer Foundation
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We describe a patient with a probable diagnosis of idiopathic late-onset cerebellar atrophy who shows improvement of limb coordination, speech, and gait following 21 days of transcranial magnetic stimulation (TMS) applied to scalp regions presumably corresponding to the cerebellum. This case study provides, for the first time, a quantitative assessment of gait improvement in response to TMS therapy in ataxia, as well as neurophysiological evidence in support of modification of cerebellar-cortical interaction that may underlie some of the improvements.
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