Journal
TRENDS IN IMMUNOLOGY
Volume 23, Issue 3, Pages 158-164Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1471-4906(01)02161-5
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Caveolae are small, cholesterol-rich, hydrophobic membrane domains, characterized by the presence of the protein caveolin and involved in several cellular processes, including clathrin-independent endocytosis, the regulation and transport of cellular cholesterol, and signal transduction. Recently, caveolae have been identified as providing a novel route by which several pathogens are internalized by antigen-presenting cells and as centers for signal transduction. Here, we review the distribution and role of caveolae and caveolin in mammalian immune cells.
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