Journal
CEREBELLUM
Volume 11, Issue 2, Pages 418-419Publisher
SPRINGER
DOI: 10.1007/s12311-011-0347-1
Keywords
Parasagittal zones; Cerebellar cortex; Parallel fibers; Purkinje cells; Zebrin II
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Funding
- NIH [NS048944, NS18338, NS062158]
- Minnesota Medical Foundation
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At the molecular and circuitry levels, the cerebellum exhibits a striking parasagittal zonation as exemplified by the spatial distribution of molecules expressed on Purkinje cells and the topography of the afferent and efferent projections. The physiology and function of the zonation is less clear. Activity-dependent optical imaging has proven a useful tool to examine the physiological properties of the parasagittal zonation in the intact animal. Recent findings show that zebrin II-positive and zebrin II-negative zones differ markedly in their responses to parallel fiber inputs. These findings suggest that cerebellar cortical excitability, information processing, and synaptic plasticity depend on the intrinsic properties of different parasagittal zones.
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