Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 37, Issue 1, Pages 3-10Publisher
EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/S0223-5234(01)01289-2
Keywords
pyrrolo[1,2-f]phenanthridines (PPHs); non-rigid analogues; anti-HIV activity
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The pyrrolo[1,2-f]phenanthridines 8-22 and the corresponding non-rigid analogues 23-41 were synthesised and their ability to inhibit the replication of HIV-1 was tested. Only the polycyclic derivatives 10, 11, and 13 showed a weak anti-HIV activity, whereas several pyrrolo-phenanthridines (8, 10, 16-18) were found to stimulate the multiplication of MT-4 cells at low concentrations. Derivative 10 demonstrated to possess the unique property of stimulating the multiplication of lymphocytes joined to HIV inhibition. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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