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MENDELEEV COMMUNICATIONS
Volume -, Issue 1, Pages 27-28Publisher
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DOI: 10.1070/MC2002v012n01ABEH001545
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The acylation of racemic 2-methyl-1,2,3,4-tetrahydroquinotine and 2-methylindoline by (S)-naproxen acyl chloride resulted in their kinetic resolution with the predominant formation of (S,S)-diastereoisomeric amides (de 78-76%), recrystallisation of which followed by acid hydrolysis gave individual (S)-isomers of heterocyclic amines.
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