Journal
JOURNAL OF MACROMOLECULAR SCIENCE-PURE AND APPLIED CHEMISTRY
Volume A39, Issue 10, Pages 1151-1181Publisher
MARCEL DEKKER INC
DOI: 10.1081/MA-120014843
Keywords
peroxidase; crosslinking; hydrogel; polyaspartic acid
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The formation of biodegradable hydrogels is reported based on enzymatic crosslinking reactions of modified polyaspartic acid. Poly(aspartic acid) polymers functionalized with aromatic groups were crosslinked in aqueous solution via peroxidase with hydrogen peroxide to form hydrogels. The reaction products were characterized based on time to gel, swelling ratio, sol fraction, storage and loss modulus, and entrapped enzyme. Optimum reaction conditions for gel synthesis were determined. Poly(aspartic acid) hydrogels have significant potential for use in biomedical applications such as in drug delivery due to the aqueous, nontoxic synthesis conditions as well as their inherent biodegradability by proteases.
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