Journal
CELL CYCLE
Volume 1, Issue 2, Pages 103-110Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.1.2.108
Keywords
Cell cycle; Cyclins; Growth factors; Oncogenes
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As formulated in 1974, the concept of the restriction point of the cell cycle was based on cell biological experiments, yet allowing accurate molecular predictions and spurring a search for the restriction factor. Although cyclin D meets the criteria of the R-factor, the picture as outlined here is more interesting and far more complex. We discuss the relationship between the restriction knot and DNA damage-checkpoints. Finally, we discuss how loss of the restriction point in cancer leads to loss of checkpoint control and to insensitivity to antimitogens including some mechanism-based anticancer therapeutics.
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