Journal
GENETIC EPIDEMIOLOGY
Volume 22, Issue 3, Pages 221-232Publisher
WILEY-LISS
DOI: 10.1002/gepi.01118
Keywords
repeated measures; heritability; statistical tests; longitudinal familial data
Funding
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG002275] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES009912] Funding Source: NIH RePORTER
- NHGRI NIH HHS [R01 HG 02275] Funding Source: Medline
- NIEHS NIH HHS [R01 ES 09912] Funding Source: Medline
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Here we present a method that permits one to evaluate genetic effects and to detect genetic linkages by using serial observations of quantitative traits in pedigrees. We developed a statistical method that incorporates longitudinal family data and genetic marker information into an estimating equations framework. With this approach, we can study changes in components over time that measure polygenic and major genetic variances as well as shared and individual-specific environmental effects. Our method provides a measure of heritability from analysis of longitudinal data. Results using longitudinal family data from the Center for Preventive Medicine (Nancy, France) are presented. The results of our analysis show that the apolipoprotein E locus has no effect on interindividual variability in systolic blood pressure. We found that the longitudinal measure of heritability of systolic blood pressure is 0.32. (C) 2002 Wiley-Liss, Inc.
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