Journal
AMINO ACIDS
Volume 23, Issue 1-3, Pages 161-162Publisher
SPRINGER-VERLAG
DOI: 10.1007/s00726-001-0122-6
Keywords
cocaine; cystine/glutamate exchanger; microdialysis
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Funding
- NIDA NIH HHS [DA12513, DA06074, DA03906, DA07288] Funding Source: Medline
- NIMH NIH HHS [MH40817] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH040817] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA003906, R37DA003906, R01DA012513] Funding Source: NIH RePORTER
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Repeated administration of cocaine lowers the basal extracellular levels of glutamate in the nucleus accumbens as measured by microdialysis. The studies presented reveal that this long-term neuroadaptation elicited by repeated cocaine results from a decrease in the activity of cystine/glutamate exchange.
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