Journal
AMINO ACIDS
Volume 23, Issue 1-3, Pages 57-63Publisher
SPRINGER WIEN
DOI: 10.1007/s00726-001-0110-x
Keywords
L-DOPA; Parkinson's disease; reactive oxygen species
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Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R15NS039272] Funding Source: NIH RePORTER
- NINDS NIH HHS [NS39272] Funding Source: Medline
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Despite its being the most efficacious drug for symptom reversal in Parkinson's disease (PD), there is concern that chronic levodopa (L-DOPA) treatment may be detrimental. In this paper we review the potential for L-DOPA to 1) autoxidize from a catechol to a quinone, and 2) generate other reactive oxygen species (ROS). Overt toxicity and neuroprotective effects of L-DOPA, both in vivo and in vitro, are described in the context of whether L-DOPA may accelerate or delay progression of human Parkinson's disease.
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