Journal
CERAMICS INTERNATIONAL
Volume 40, Issue 8, Pages 12617-12621Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceramint.2014.04.100
Keywords
Hydroxyapatite; Microspheres; Porosities; Pore structures
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Funding
- National Natural Science Foundation of China [51172288]
- Ph.D. Programs Foundation of Ministry of Education of the People's Republic of China [20110162130003, 20110162110044]
- Hunan Provincial Natural Science Foundation of China [11JJ1008]
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Porous hydroxyapatite (HA) microspheres with the main particle size of 42-50 mu m were fabricated using a novel ITSD technique. Pore structures transformed from aligned pores to cellular pores, with the increase of PVA contents. The percentages of GS loadings decreased from 41.8% to 30.9%, with porosities decreasing from 58.7% to 40.2%. Gentamicin was successfully loaded into porous HA microspheres and about 80% of loaded-GS amount was released from GS-loaded HA microspheres during 48 h period. (C) 2014 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
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