Journal
CERAMICS INTERNATIONAL
Volume 40, Issue 1, Pages 985-991Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceramint.2013.06.095
Keywords
Films; Composites; Mechanical properties; Apatite
Categories
Funding
- National Natural Science Foundation of China [31201855]
- Rearing Fund for Innovative Research Team in the Sericulture Industry [2011R50028]
- Key Program in Medical Science Research of Military [BWS11C061]
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A flexible ethanol-treated sericin film was prepared and used to form a hydroxyapatite/sericin composite film by mineralizing it with simulated body fluids solution. The hydroxyapatite mineral deposited on the surface of the ethanol-treated sericin film was characterized by Scanning Electron Microscopy, Fourier Transform Infrared Spectroscopy, Energy Dispersive X-Ray Spectroscopy, and X-ray diffraction analysis. Results indicated that the quantity of deposited minerals increased with increasing mineralization time and showed a thee-dimensional structure. This structure was determined to be calcium-deficient carbonate apatite with poor crystallinity and growth in the direction of the c-axis similar to natural bone mineral. The mechanical properties of the hydroxyapatite/sericin composite film decreased with increasing mineralization time. XTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tests showed that the hydroxyapatite/sericin composite film promoted cell viability, which is beneficial for its application in bone tissue engineering. (C) 2013 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
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