Journal
PSYCHONEUROENDOCRINOLOGY
Volume 27, Issue 1-2, Pages 127-138Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0306-4530(01)00040-3
Keywords
maternal separation; dopamine; dopamine transporter; cocaine; stress
Categories
Ask authors/readers for more resources
Repeated periods of maternal separation in the early life of rats decreased dopamine transporter expression and significantly increased dopamine responses to stress, and behavioral responses to either stress or cocaine. As adults, maternal separation animals showed increased sensitivity to the effects of cocaine on locomotor activity and greater sensitivity to stress-induced sensitization to the effects of amphetamine on locomotor activity. These findings raise the possibility that in addition to effects on stress reactivity, early life events might dispose individuals to illness in later life through effects on very specific neuro transmitter systems. (C) 2001 Published by Elsevier Science Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available