Journal
CARDIOLOGY
Volume 97, Issue 4, Pages 218-225Publisher
KARGER
DOI: 10.1159/000063110
Keywords
heart failure; thyroid hormone analog; serum cholesterol
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After an initial safety study in 7 normal volunteers, a randomized double-blind comparison was made between 3,5-diiodothyropropionic acid (DITPA) and placebo in 19 patients with moderately severe congestive failure. In heart failure patients receiving the drug for 4 weeks, cardiac index was increased (p = 0.04) and systemic vascular resistance index was decreased (p = 0.02). Systolic cardiac function was unchanged but isovolumetric relaxation time was decreased significantly, suggesting improvement in diastolic function. Total serum cholesterol (p = 0.005) and triglycerides (p = 0.01) also were decreased significantly. DITPA could represent a useful new agent for treatment of congestive heart failure. Copyright (C) 2002 S. KargerAG, Basel.
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