Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 7, Issue 1, Pages 123-129Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.1428291
Keywords
optical coherence tomography; Doppler flowmetry
Funding
- NATIONAL EYE INSTITUTE [R24EY013015] Funding Source: NIH RePORTER
- NEI NIH HHS [R24 EY13015-01] Funding Source: Medline
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Color Doppler optical coherence tomography (CDOCT) is a functional extension of optical coherence tomography (OCT) that can image flow in turbid media. We have developed a CDOCT system capable of imaging flow in real time. Doppler processing of the analog signal is, accomplished in hardware in the time domain using a novel autocorrelation technique. This Doppler processing method is compatible with a high speed OCT system capable of imaging in real time. Using this system, we demonstrate cross-sectional imaging of bidirectional flow with CDOCT at four frames per second in a tissue-simulating phantom consisting of intralipid solution flowing in glass capillaries. As a demonstration of real-time imaging of blood flow in vivo we imaged pulsatible blood flow in a rat femoral artery at eight frames per second. Issues of velocity sensitivity, imaging speed, and range of, velocity measurement are discussed, as well as potential applications of real-time CDOCT. (C) 2002 Society of Photo-Optical Instrumentation Engineers.
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