Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 13, Issue 12, Pages 1353-1366Publisher
VSP BV
DOI: 10.1163/15685620260449741
Keywords
dexamethasone; leukocytes; polyethyleneglycol; glutaraldehyde; subcutaneous cage implant
Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL063686] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB000290] Funding Source: NIH RePORTER
- NHLBI NIH HHS [HL-63686] Funding Source: Medline
- NIBIB NIH HHS [EB-00290] Funding Source: Medline
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The in vivo host response to two gelatin-based hydrogel systems of varying crosslinking modalities and loaded with the anti-inflammatory agent dexamethasone sodium phosphate was investigated. Either gelatin was chemically crosslinked with glutaraldehyde, or polyethyleneglycol diacrylate was photopolymerized around gelatin to form interpenetrating networks. The subcutaneous cage implant system was utilized to determine differential leukocyte concentrations in the inflammatory exudate surrounding the materials as indices for biocompatibility and drug efficacy in vivo. Most of the crosslinked gelatin-based materials, either via glutaraldehyde fixation or interpenetrating network formation, elicited stronger inflammatory responses than either of the starting materials, gelatin and polyethyleneglycol diacrylate. In general, dexamethasone delayed and intensified the inflammatory response. The loss of material mass did not correlate directly with the degree of cellular inflammatory response, but increased with longer implantation time and decreased with more extensive fixation.
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