Journal
IMMUNOLOGIC RESEARCH
Volume 26, Issue 1-3, Pages 7-13Publisher
HUMANA PRESS INC
DOI: 10.1385/IR:26:1-3:007
Keywords
complement; anaphylatoxin receptors; glial cells; neurons; experimental allergic encephalomyelitis; neurobiology
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Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P01NS029719] Funding Source: NIH RePORTER
- NINDS NIH HHS [NS 29719] Funding Source: Medline
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The complement system is well represented in the central nervous system. Glial cells and neurons produce or express all of the activation and regulatory proteins and the C3a/C5a receptors. Inhibition of complement activation is protective in experimental allergic encephalomyelitis, the animal model for multiple sclerosis, suggesting possible therapeutic approaches for human disease. New findings indicate that the C3a/C5a receptors are widely expressed in neurons and may modulate neuronal function.
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