Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 2, Issue 6, Pages 553-563Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557023405549
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Funding
- [AI 49785]
- [AI43094]
- [AI41398]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI049785, R44AI043094, R01AI041398, R43AI043094] Funding Source: NIH RePORTER
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Polyamines are essential cell constituents for all organisms. The present review highlights important differences in the synthesis, degradation, and interconversion of polyamines between the protozoan parasites (Trypanosoma brucei, Trypanosoma cruzi, Cryptosporidium parvum and Trichomonas vaginalis) and their mammalian hosts. Approaches include development of mono- and di-substituted polyamine analogs targeting polyamine interconversion, as well as more traditional targeting of synthetic enzymes and related pathways.
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