Journal
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
Volume 1, Issue 1, Pages 31-49Publisher
BENTHAM SCIENCE PUBL
DOI: 10.2174/1568007023339472
Keywords
c-Jun N-terminal kinase (JNK); neuron; Alzheimer's; Huntington's; Parkinson's; Stroke; mixed lineage kinase (MLK)
Categories
Ask authors/readers for more resources
The c-Jun N-terminal Kinase (JNK) pathway leading to c-Jun phosphorylation plays a causal role in apoptosis of isolated primary embryonic neurons and of multiple neuronal cell lines following a wide variety of stimuli. Activation of this pathway may also contribute to the neuronal atrophy and death that is associated with neurodegenerative pathological conditions including Alzheimer's, Parkinson's, Huntington's Diseases and stroke. Here, the data that providelinks between the activation of the JNK pathway and its potential to play an operative role in CNS disease are reviewed. Also included is the progress on development of inhibitors targeting the JNK pathway for therapeutic benefit.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available