Journal
INTERNATIONAL JOURNAL OF HYPERTHERMIA
Volume 18, Issue 1, Pages 25-30Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/02656730110083756
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There are two evidence based therapeutic options for locally advanced cervical cancer: Radiotherapy and concurrent chemotherapy (cisplatin alone or combined with other drugs) or radiation and hyperthermia, documented in randomised trials. The weight of evidence is less for the most advanced stages. Combination of all three options are currently tested in several centres with good clinical response and acceptable toxicity. Based on a pragmatic approach we propose to proceed with a trial selecting cisplatin concurrent with radiation therapy as the standard arm to be compared with the same regimen with the addition of hyperthermia once a week.
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