Journal
BREAST CANCER RESEARCH
Volume 4, Issue 6, Pages 240-243Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/bcr539
Keywords
antiprogestins; breast cancer; crosstalk; ligand independent; medroxyprogesterone; progesterone receptor
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Progesterone and estradiol, and their nuclear receptors, play essential roles in the physiology of the reproductive tract, the mammary gland and the nervous system. Estrogens have traditionally been considered associated with an increased risk of breast cancer. There is, however, compelling evidence that progesterone plays an important role in breast cell proliferation and cancer. Herein, we review the possible role of progestins and the progesterone receptor-associated signaling pathways in the development of breast cancer, as well as the therapeutic possibilities arising from our growing knowledge of the activation of the progesterone receptor by other proliferative mechanisms.
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