Journal
IMMUNOLOGIC RESEARCH
Volume 26, Issue 1-3, Pages 199-206Publisher
HUMANA PRESS INC
DOI: 10.1385/IR:26:1-3:199
Keywords
integrins; leukocytes; diffusion; cell adhesion; cytoskeleton
Categories
Ask authors/readers for more resources
Leukocyte adhesion must be tightly controlled in order for leukocytes to patrol the body as nonadherent cells, yet stop and emigrate from the blood into tissues at sites of infection or inflammation. A key element in this process is activation of beta(2) integrins. While beta(2) integrin activation involves conformational changes that increase affinity for ligand, evidence is accumulating that rearrangement of integrins, resulting in increases in avidity, is at least as important in regulating binding capacity. Recent work has established the importance of diffusion and rearrangement of integrins to activation of leukocyte adhesion, and has begun to unravel the molecular basis of its regulation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available