Journal
NEUROTOXICITY RESEARCH
Volume 4, Issue 5-6, Pages -Publisher
SPRINGER
DOI: 10.1080/10298420290030569
Keywords
Development; HPA axis; Adrenal; Glucocorticoids; ACTH; Hypothalamus
Categories
Funding
- National Institute of Child Health and Human Development [HD-02881]
- National Institute of Mental Health (NIMH) [MH-45006]
- U.S. Public Health Service Research Scientist Award from NIMH [MH-19936]
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There is a growing literature that indicates that exposure to elevated levels of glucocorticoids can result in long term consequences for the developing brain. In the developing rodent there is a period from about day 4-14 when the adrenal response to stress is either minimal or non-existent thus resulting in stable low levels of circulating glucocorticoids. This has been designated as the stress hypo-responsive period (SHRP). Numerous experiments have demonstrated that maternal factors are critical for the regulation of the pup's hypothalamicpituitary-adrenal (HPA) axis and the maintenance of the SHRP. Following 24h of maternal deprivation the neonatal rat shows elevated basal levels of corticosterone and exhibits a robust corticosterone and ACTH response to mild stress. Further c-fos mRNA in the paraventricular nucleus is enhanced following stress in deprived pups. At least three aspects of maternal behavior play a role in the regulation of the HPA axis during development. Tactile stimulation appears capable in inhibiting most of the brain-related changes that occur following maternal deprivation. Feeding is essential for maintaining the adrenal unresponsive and reduces the sensitivity of the adrenal to ACTH. Passive contact suppresses the response to stress. In the adult cordicotropin-releasing hormone (CRH) is the major neuropetide that controls pituitary ACTH secretion. In the maternally deprived pup CRH gene transcription is down regulated and arginine vasopressin (AVP) appears to assume the major regulatory hormone that modulates ACTH. These data all indicate that maternal factors are responsible for actively inhibiting the endocrine responses to stress postnatally. Further, maternal deprivation also results in increased cell death in several brain regions. This during development most of the peripheral and central stress reponsive systems are capable of being activated. However, under conditions of normal dam-pup interactions these responses are mostly supressed by the dam's behavioral interaction with the pups thus preventing the potential toxic effects of increased secretion of glucocorticoids during critical periods of brain development.
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