Journal
SOZIAL-UND PRAVENTIVMEDIZIN
Volume 47, Issue 6, Pages 359-365Publisher
BIRKHAUSER VERLAG AG
DOI: 10.1007/s000380200003
Keywords
case-control study; epidemiology; history
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The first modern case-control study was Janet Lane-Claypon's study of breast cancer in 1926, but the design was used only sporadically in medicine and the social sciences until 1950, when four published case-control studies linked smoking and lung cancer. These 1950 studies synthesized the essential elements of the case-control comparison, produced a conceptual shift within epidemiology, and laid the foundation for the rapid development of the case-control design in the subsequent half century.
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