Journal
IMMUNOLOGIC RESEARCH
Volume 25, Issue 2, Pages 143-153Publisher
HUMANA PRESS INC
DOI: 10.1385/IR:25:2:143
Keywords
lupus; mouse; knock out; autoimmune
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Funding
- NIAMS NIH HHS [R01AR45499] Funding Source: Medline
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MRL-MPJ Fas(1pr) (MRL/1pr) mice are a prototypic murine model for lupus characterized by an accelerated autoimmune syndrome. Disease begins as early as 8-wk-of-age in these animals with polyclonal B cell activation and elevated levels of serum IgM. By 12 to 16-wk-of-age MRL/1pr mice begin to produce a variety of autoantibodies including anti-dsDNA and anti-ss-DNA antibodies. From 16 to 24 wk, MRL/1pr mice develop proliferative immune complex mediated glomerulonephritis, vasculitis, arthritis, and massive lymphadenopathy that results in renal failure and death in 50% of the mice by 24-wk-of-age. This review will discuss several different genetic knockout experimental approaches used to study disease expression in MRL/1pr mice including various approaches in our laboratory aimed at autoantibody (Ab) production and inflammatory mediators.
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