Journal
TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS
Volume 22, Issue 2, Pages 103-111Publisher
WILEY-LISS
DOI: 10.1002/tcm.10008
Keywords
anti-oxidants; comet assay; Agaricus bisporus; Ganoderma lucidum; reactive oxygen species
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Aqueous extracts of the sporophores of eight mushroom species were assessed for their ability to prevent H2O2-induced oxidative damage to cellular DNA using the single-cell gel electrophoresis (Comet) assay. The highest genoprotective effects were obtained with cold (20degreesC) and hot (100degreesC) water extracts of Agaricus bisporus and Ganoderma lucidum fruit bodies, respectively. No protective effects were observed with Mushroom Derived Preparations (MDPs) from Flammulina velutipes, Auricularia auricula, Hypsizygus marmoreus, Lentinula edodes, Pleurotus sajor-caju, and Volvariella volvacea. These findings indicate that some edible mushrooms represent a valuable source of biologically active compounds with potential for protecting cellular DNA from oxidative damage. (C) 2002 Wiley-Liss, Inc.
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