Journal
ARTHRITIS RESEARCH
Volume 4, Issue 1, Pages 71-76Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/ar386
Keywords
ankylosing spondylitis; CD8(+) T suppressor cells; CD28 molecule; cytotoxicity; interferon-gamma
Categories
Ask authors/readers for more resources
Circulating CD8+ CD28(-) T cells were found to be expanded more in patients with ankylosing spondylitis than in an age-matched healthy population (41.2 +/- 17.7% versus 18.6 +/- 7.6%). The level of CD8+ CD28- T cells was dependent on the disease status, but was independent of age. Most of the CD8+ CD28- T cells produced perforin after stimulation in vitro, in contrast to their CD8+ CD28+ counterparts. From the clinical perspective, the percentage of the cytotoxic CD8+ CD28- T cells reflected a more severe course of disease, as it correlated with distinct movement restrictions, as well as the metrology score summarizing cervical rotation (in sitting position), chin-to-jugulum distance, thoracic Schober, chest expansion, and fingers-to-floor distance (P = 0.032).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available