Journal
BIOGERONTOLOGY
Volume 3, Issue 1-2, Pages 13-17Publisher
KLUWER ACADEMIC PUBL
DOI: 10.1023/A:1015226524335
Keywords
ageing; fibroblast; senescence; stress
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The similarities between the biomarkers of stress-induced premature senescence and replicative senescence are reviewed. The possibility of existence of 'molecular scars' i.e. long-term changes observed after subcytotoxic stress and not observed in replicative senescence, is considered. Lastly, the likeliness of existence of stress-induced premature senescence in vivo is discussed. The possible effects on normal and pathological tissue ageing are predicted.
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