Journal
CHROMOSOME RESEARCH
Volume 10, Issue 1, Pages 55-61Publisher
KLUWER ACADEMIC PUBL
DOI: 10.1023/A:1014222311431
Keywords
comparative mapping; evolutionary breakpoints; in-situ hybridization; phylogeny; primates; Y chromosome
Ask authors/readers for more resources
For a long time, the evolutionary relationship between human and African apes, the 'trichotomy problem. has been debated with strong differences in opinion and interpretation. Statistical analyses of different molecular DNA data sets have been carried out and have primarily supported a Homo-Pall clade. An alternative way to address this question is by the comparison of evolutionarily relevant chromosomal breakpoints. Here., we made use of a P1-derived artificial chromosome (PAC) /bacterial artificial chromosome (BAC) contig spanning approximately 2.8 Mb on the long arm of the human Y chromosome, to comparatively map individual PAC clones to chromosomes from great apes, gibbons, and two species of Old World monkeys by fluorescence in-situ hybridization. During our search for evolutionary breakpoints on the Y chromosome, it transpired that a transposition of an approximately 100-kb DNA fragment from chromosome 1 onto the Y chromosome must have occurred in a common ancestor of human, chimpanzee and bonobo. Only the Y chromosomes of these three species contain the chromosome-1-derived fragment; it could not be detected on the Y chromosomes of gorillas or the other primates examined. Thus, this shared derived (synapomorphic) trait provides clear evidence for a Homo-Pan clade independent of DNA sequence analysis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available