Journal
CEPHALALGIA
Volume 34, Issue 14, Pages 1169-1180Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0333102414534085
Keywords
Carbon monoxide; haeme oxygenase; headache; pain processing; cerebral vessels
Categories
Funding
- Capital Region of Denmark
- Foundation for Health Research [A4620]
- Novo Nordisk Foundation [A14333]
- Danish Headache Foundation
- Novo Nordisk Fonden [NNF11OC1014333] Funding Source: researchfish
Ask authors/readers for more resources
Introduction Carbon monoxide was previously considered to just be a toxic gas. A wealth of recent information has, however, shown that it is also an important endogenously produced signalling molecule involved in multiple biological processes. Endogenously produced carbon monoxide may thus play an important role in nociceptive processing and in regulation of cerebral arterial tone. Discussion Carbon monoxide-induced headache shares many characteristics with migraine and other headaches. The mechanisms whereby carbon monoxide causes headache may include hypoxia, nitric oxide signalling and activation of cyclic guanosine monophosphate pathways. Here, we review the literature about carbon monoxide-induced headache and its possible mechanisms. Conclusion We suggest, for the first time, that carbon monoxide may play an important role in the mechanisms of migraine and other headaches.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available