Journal
CEPHALALGIA
Volume 34, Issue 12, Pages 959-967Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0333102414527016
Keywords
Migraine; FHM; genetics; magnetic resonance spectroscopy; imaging
Categories
Funding
- Netherlands Organisation for Scientific Research (NWO) [903-52-291, Vici 918.56.602, 907-00-217, Vidi 917-11-319]
- Centre for Medical Systems Biology (CMSB)
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Aim:The aim of this study was to assess biochemical changes in the brain of patients with hemiplegic migraine in between attacks. Methods:Eighteen patients with hemiplegic migraine (M:F, 7:11; age 38 +/- 14 years) of whom eight had a known familial hemiplegic migraine (FHM) mutation (five in the CACNA1A gene (FHM1), three in the ATP1A2 gene (FHM2)) and 19-age and sex-matched healthy controls (M:F, 7:12; mean age 38 +/- 12 years) were studied. We used single-voxel 7 tesla 1 H-MRS (STEAM, TR/TM/TE = 2000/19/21 ms) to investigate four brain regions in between attacks:cerebellum, hypothalamus, occipital lobe, and pons. Results:Patients with hemiplegic migraine showed a significantly lower total N-acetylaspartate/total creatine ratio (tNAA/tCre) in the cerebellum (median 0.73, range 0.59-1.03) than healthy controls (median 0.79, range (0.67-0.95); p = 0.02). In FHM1 patients with a CACNA1A mutation, the tNAA/tCre was lowest. Discussion:We found a decreased cerebellar tNAA/tCre ratio that might serve as an early biomarker for neuronal dysfunction and/or loss. This is the first high-spectral resolution 7 tesla 1 H-MRS study of interictal biochemical brain changes in hemiplegic migraine patients.
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