Journal
CEPHALALGIA
Volume 32, Issue 13, Pages 998-1004Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0333102412453955
Keywords
Cluster headache; habituation; trigeminal nociception; nociceptive blink reflex
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Funding
- Grunenthal
- Deutsche Gesellschaft fur Muskelkranke
- University of Halle-Wittenberg
- MSD
- Berlin Chemie
- Medtronic
- Bohringer Ingelheim
- Boston Scientific
- St. Jude Medical
- Medtronic Medical
- Linde AG
- Berlin-Chemie
- Allergan
- Almirall
- AstraZeneca
- Bayer
- Galaxo-Smith-Kline
- Janssen-Cilag
- Pfizer
- German Research Council (DFG)
- German Ministry of Education and Research (BMBF)
- European Union
- Biogen
- Merck
- German Federal Ministry of Education and Research BMBF [01EM 0513]
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Background: Analysis of habituation patterns in patients with primary headache disorders allows the detection of changes to the excitability level of the trigeminal nociceptive system. Previous studies demonstrated a habituation deficit to painful stimuli in migraine and it was suggested that similar observations could be made in cluster headache (CH). Methods: Habituation of the nociceptive'' blink reflex (nBR) (R2 response) was studied in 66 CH patients (18 episodic CH inside bout, 28 episodic CH outside bout, 20 chronic CH) as well as in 30 healthy controls in a case-control study design. Results: Habituation behaviour was similar in CH and healthy controls as well as in CH subtypes. No side-to-side differences of habituation between headache side and non-headache side were detected. Conclusion: Our results did not detect an altered habituation in CH patients. Despite clinical similarities, migraine and CH seem not to share the same pathophysiological mechanisms in this regard.
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