Journal
CEPHALALGIA
Volume 31, Issue 12, Pages 1291-1300Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0333102411417466
Keywords
Migraine; cognitive function; epidemiology
Categories
Funding
- French National Research Agency (ANR, Agence Nationale de la Recherche)
- National Institute on Aging [AG00158]
- Harvard School of Public Health
- Department of Epidemiology at the Harvard School of Public Health
- EISAI
- US National Institutes of Health
- Robert Wood Johnson Foundation
- MacArthur Foundation Network on SES and Health
- Milton Fund for Harvard University Junior Faculty
- American Heart Association
- French National Research Agency (ANR)
- Sanofi-Synthelabo
- Merck Sharp Dohme
- Servier company
- Merck
- Migraine Research Foundation
- Parkinson's Research Foundation
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Background: Previous studies on migraine and cognition have shown mixed results. However, many could not assess the relationship between migraine and change in cognitive function or only used a limited number of cognitive tests. Methods: Prospective cohort study among 1170 participants of the Epidemiology of Vascular Ageing Study who provided information about migraine status and completed cognitive testing. Participants were classified as having no severe headache, non-migraine headache and migraine. Cognitive functioning was measured at up to four time points using nine different cognitive functioning tests. Linear mixed effects models were used to evaluate the relationship between migraine status and change in cognitive function. Results: Of the 1170 participants, 938 had no severe headache, 167 had migraine, and 65 had non-migraine headache. After adjusting for age, gender, education and smoking status, people with migraine or non-migraine headache did not experience a greater rate of cognitive decline than those without headache or migraine in any domain (for the Mini Mental State Examination (MMSE), p-values were 0.68 for the non-migraine headache and time interaction and 0.85 for the migraine and time interaction) during 4-5 years of follow-up. For the Wechsler Adult Intelligence Scale-Revised, those with migraine declined less over time (p-value = 0.02). Conclusion: Migraine was not associated with faster cognitive decline over time.
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