Journal
CEPHALALGIA
Volume 31, Issue 1, Pages 6-12Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0333102410365108
Keywords
migraine; cutaneous allodynia; central sensitisation; quantitative sensory testing; pain thresholds
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Funding
- NIH [K24DA00417, UL1 RR024992, KL2 RR024994, RO1NS48602]
- NATIONAL CENTER FOR RESEARCH RESOURCES [UL1RR024992, KL2RR024994] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS048602] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [K24DA000417] Funding Source: NIH RePORTER
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Objective: To determine if migraineurs have evidence of interictal cutaneous sensitisation. Subjects and methods: Thermal and mechanical pain thresholds in 20 episodic migraineurs, 20 chronic migraineurs, and 20 non-migraine control subjects were compared. Quantitative sensory testing was conducted when subjects had been migraine-free for at least 48 h. Heat, cold and mechanical pain thresholds, and heat and cold pain tolerance thresholds were measured. Results: Thermal pain thresholds and thermal pain tolerance thresholds differed significantly by headache group (P = 0.001). During the interictal period, episodic and chronic migraineurs were more sensitive to thermal stimulation than non-migraine controls. Conclusions: Interictal sensitisation may predispose the migraineur to development of headaches, may be a marker of migraine activity, and a target for treatment.
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