Journal
CEPHALALGIA
Volume 29, Issue 10, Pages 1095-1114Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1111/j.1468-2982.2009.01982.x
Keywords
Spreading depression; migraine; prophylaxis; experimental models; drug screening
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Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS061505] Funding Source: NIH RePORTER
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Despite the relatively well-characterized headache mechanisms in migraine, upstream events triggering individual attacks are poorly understood. This lack of mechanistic insight has hampered a rational approach to prophylactic drug discovery. Unlike targeted abortive and analgesic interventions, mainstream migraine prophylaxis has been largely based on serendipitous observations (e.g. propranolol) and presumed class effects (e.g. anticonvulsants). Recent studies suggest that spreading depression is the final common pathophysiological target for several established or investigational migraine prophylactic drugs. Building on these observations, spreading depression can now be explored for its predictive utility as a preclinical drug screening paradigm in migraine prophylaxis.
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