Journal
RADIOLOGY
Volume 222, Issue 1, Pages 212-218Publisher
RADIOLOGICAL SOC NORTH AMERICA
DOI: 10.1148/radiol.2221010626
Keywords
anisotropy; brain, diffusion; brain, growth and development; brain, MR; brain, white matter; children, central nervous system; diffusion tensor; magnetic resonance (MR), diffusion study; myelin
Funding
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD038578] Funding Source: NIH RePORTER
- NICHD NIH HHS [R01 HD038578-05, R01 HD 38578-02, R01 HD038578] Funding Source: Medline
Ask authors/readers for more resources
PURPOSE: To evaluate differences in white matter diffusion properties as a function of age in healthy children and adolescents. MATERIALS AND METHODS: Echo-planar diffusion-tensor magnetic resonance (MR) imaging was performed in 33 healthy subjects aged 5-18 years who were recruited from a functional imaging study of normal language development. Results of neurologic, psychologic, and structural MR imaging examinations were within the normal range for all subjects. The trace of the apparent diffusion coefficient and fractional anisotropy in white matter were correlated as a function of age by using Spearman rank correlation. RESULTS: Statistically significant negative correlation of the trace of the apparent diffusion coefficient with age was found throughout the white matter. Significant positive correlation of fractional anisotropy with age was found in the internal capsule, corticospinal tract, left arcuate fasciculus, and right inferior longitudinal fasciculus. CONCLUSION: Diffusion-tensor MR imaging results indicate that white matter maturation assessed at different ages involves increases in both white matter density and organization during childhood and adolescence. The trace of the apparent diffusion coefficient and fractional anisotropy may reflect different physiologic processes in healthy children and adolescents.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available