Journal
JOURNAL OF VIROLOGY
Volume 76, Issue 6, Pages 3023-3030Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.76.6.3023-3030.2002
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI023946] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI23946, R01 AI023946] Funding Source: Medline
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The Norwalk virus (NV) capsid protein was expressed using Venezuelan equine encephalitis virus replicon particles (VRP-WI). VRP-NV1 infection resulted in large numbers of recombinant NV-like particles that were primarily cell associated and were indistinguishable from NV particles produced from baculoviruses. Mutations located in the N-terminal and PI domains of the W capsid protein ablated capsid self-assembly in mammalian cells.
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