Journal
BONE MARROW TRANSPLANTATION
Volume 29, Issue 5, Pages 457-458Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bmt.1703379
Keywords
hypereosinophilic syndrome; allogeneic stem cell transplantation; non-myeloablative conditioning
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A male patient with hypereosinophilic syndrome (HES) underwent an allogeneic blood stem cell transplantation from a female donor following non-myeloablative conditioning consisting of a 2 Gy dose of TBI and fludarabine 30 mg/ml(2) intravenously on three days. Before transplantation 100% of the mitotic bone marrow cells of the patient showed a clonal karyotype abnormality. Three months after the transplantation eosinophilia had resolved and a chromosome analysis revealed normal female karyotype. The present study shows that stem cell transplantation after non-myeloablative conditioning may have curative potential for HES.
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