Journal
FERTILITY AND STERILITY
Volume 77, Issue 3, Pages 505-510Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0015-0282(01)03217-4
Keywords
IVF; ICSI; probability; cumulative live birth; age
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Objective: To assess the probability of live birth after three available in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles. Design: Retrospective, observational study. Setting: University hospital. Patient(s): Nine hundred seventy-four couples who started their first conventional IVF or ICSI cycle between January 1996 and December 1997, A total of 1985 stimulated cycles were initiated. Intervention(s): Analysis of the cumulative live birth rate using the life-table approach with and without taking dropouts into account. Main Outcome Measure(s): Cumulative live birth rate. Result(s): The overall cumulative live birth rate after three completed stimulated cycles (including freezing/ thawing cycles) was 65.5% with an optimistic approach. For the realistic and pessimistic approaches the corresponding figures were 63.1% and 55.5%, respectively. Unexpectedly, 65% of couples not achieving a live birth interrupted the full treatment program of three cycles. Conclusion(s): The cumulative live birth rate gives the couple a more accurate prognosis of achieving a live birth after IVF/ICSI than the statistics usually provided. With the realistic estimation, 63% of the couples achieved childbirth after three available conventional IVF or ICSI cycles. Further studies are required to investigate the high drop-out rate. (Fertil Sterl((R)) 2002;77:505-10. (C) 2002 by American Society for Reproductive Medicine).
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