Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 948, Issue 1-2, Pages 163-169Publisher
ELSEVIER
DOI: 10.1016/S0021-9673(01)01457-1
Keywords
molecular imprinting; solid-phase extraction; caffeine; theophylline; theobromine; xanthines
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A molecularly imprinted polymer (MIP) was prepared with caffeine as the template molecule. Thermal polymerisation (60degreesC) was optimised, varying ratios of monomer, cross linker and template. The polymer was used as a solid-phase extraction (SPE) sorbent, for selective trapping and pre-concentration of caffeine. Caffeine was loaded on the MIP-SPE cartridge using different loading conditions (solvents, pH value), Washing and elution of the caffeine bound to the MIP was studied utilising different protocols. The extraction protocol was successfully applied to the direct extraction of caffeine from beverages and spiked human plasma. (C) 2002 Elsevier Science B.V. All rights reserved.
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