Journal
CHEMICAL COMMUNICATIONS
Volume -, Issue 4, Pages 291-301Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b108995c
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Rapid progress on the catalytic mechanism and substrate recognition by squalene-hopene cyclase, which has occurred only in the last several years, is reported. A series of site-directed mutation experiments and some squalene analogues have provided deep insight into the polycyclization mechanism and catalytic sites in conjunction with the information from X-ray crystal data.
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