Journal
CENTRAL EUROPEAN JOURNAL OF CHEMISTRY
Volume 12, Issue 9, Pages 962-967Publisher
SCIENDO
DOI: 10.2478/s11532-014-0541-3
Keywords
Bacterial cellulose; Box-Behnken Design; Drug release
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Funding
- [POSDRU/107/1.5/S/76903]
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Bacterial cellulose (BC), a natural polymer with unique physical and mechanical properties, has several applications in the biomedical field, including drug loading and controlled drug delivery. For this study, a Box-Behnken experimental design was employed as a statistical tool to optimize the release of a model drug, amoxicillin, from BC membranes. Independent variables studied were the concentration of the drug (X-1), the concentration of glycerol (X-2) and the concentration of a permeation enhancer (X-3). From the variables studied, drug concentration had the highest effect on drug release. Among the other independent variables, th linear and quadratic X-2 terms, the linear X-3 term and the interaction term X2X3 were found to affect the release of amoxicillin from bacterial cellulose membranes.
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