Journal
CENTRAL EUROPEAN JOURNAL OF CHEMISTRY
Volume 10, Issue 1, Pages 216-223Publisher
VERSITA
DOI: 10.2478/s11532-011-0131-6
Keywords
Lipophilicity; Gradient reversed-phase high-performance liquid chromatography (RP-HPLC)
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Funding
- Polish State Committee for Scientific Research [N N405 024340]
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The lipophilicity values of selected acridinone (imidazoacridinone and triazoloacridinone) derivatives were measured by gradient reversed-phase high-performance liquid chromatography (RP-HPLC) using a C18 stationary phase with a water/acetonitrile mixture as a mobile phase. The retention times obtained served as input data and appropriate log k(w) values (i.e., the retention factor log k(w) extrapolated to 0% organic modifier) as an alternative to log P were calculated using the DryLab program. The relationships between the lipophilicity (log k(w)) and the chemical structure of the studied compounds, as well as correlation between experimentally determined lipophilicities (log k(w)) and log P data calculated using some commonly available software, are discussed.
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